Selank 10mg
$72.00
Selank 10mg is a high-purity synthetic analog of the naturally occurring immunomodulatory peptide Tuftsin. This heptapeptide is specifically engineered for advanced research into neurobiology, focusing on its potential anxiolytic and cognitive-enhancing properties.
| Property | Specification |
|---|---|
| Compound Name | Selank |
| CAS Number | 129954-34-3 |
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| Parent Peptide | Tuftsin (Thr-Lys-Pro-Arg) + Pro-Gly-Pro stabilizing extension |
| Molecular Formula | C₃₃H₅₇N₁₁O₉ |
| Molecular Weight | ~751.9 g/mol |
| Class | Synthetic heptapeptide (anxiolytic / immunomodulatory) |
| Purity Rating | >99% (HPLC & MS verified) |
| Format | White lyophilized powder |
| Solubility | Water-soluble |
| Storage | -20°C, protected from light and moisture |
Selank 10mg for Sale | 99% Pure Anxiolytic Tuftsin Analog (Anti-Anxiety Neuropeptide)
Benzodiazepines calm anxiety — and then bill you for it with sedation, tolerance, dependence, and withdrawal. Russian researchers set out to design an anxiolytic that skipped all of that, and the result was Selank. In elevated plus-maze studies, its anxiety-reducing activity was comparable to diazepam and phenibut — but without the motor impairment or sedation those compounds produce (Seregin et al., PMID 19916388, via Spartan Peptides, 2026). That’s the whole reason Selank became one of the most carefully studied neuropeptides in anxiety research.
Selank 10mg is the high-purity research form of that heptapeptide — a synthetic analog of the immune peptide tuftsin, verified 99%+ pure and lyophilized for the lab. It’s a rare thing: a nootropic-anxiolytic peptide that actually crossed from the bench into regulatory approval (in Russia). Below is the real science, the honest limits of the evidence, and where to buy it.
Scope note: research-grade material for in-vitro and laboratory research by qualified professionals only. Not FDA-approved (approved only in Russia), not for human or veterinary use, and nothing here is a dosing protocol.
From Immune Peptide to Anxiety Tool: The Tuftsin Origin
Selank‘s backstory explains a lot about how it works. It was built by the Institute of Molecular Genetics at the Russian Academy of Sciences from tuftsin — a naturally occurring tetrapeptide (Thr-Lys-Pro-Arg) fragment of the immunoglobulin G heavy chain that plays a role in immune function
Native tuftsin is fragile and short-lived, so the designers added three more residues — Pro-Gly-Pro — to stabilize the molecule and extend its central activity, producing the heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro. That tuftsin heritage is why Selank is unusual: it carries genuine immunomodulatory activity and anxiolytic activity in the same small molecule — a dual profile no Western anxiolytic replicates
How Selank Works: Four Mechanisms, No Sedation
Here’s the part that makes Selank mechanistically interesting — it doesn’t have one action, it has a network of them, and crucially, none involves the benzodiazepine receptor site.
- Indirect GABAergic modulation. Selank doesn’t bind the GABA-A receptor directly like a benzo does. Instead it appears to increase GABA-A receptor expression and stabilize GABAergic tone indirectly. That indirect route is the leading explanation for why it calms anxiety without sedation or dependence.
- Enkephalinase inhibition. As a tuftsin derivative, Selank slows the breakdown of endogenous enkephalins — short opioid-like peptides tied to mood and stress. This enkephalin-stabilizing effect is one of its most distinctive features
- BDNF upregulation. Preclinical work reports Selank raises brain-derived neurotrophic factor in the hippocampus, supporting neuroplasticity — the plausible substrate for its reported effects on learning and attention.
- Cytokine and immune modulation. True to its tuftsin origin, Selank reduces pro-inflammatory cytokines including IL-6, TNF-α, and IL-1β under stress, while preserving immune competence. That’s the basis for research on the stress-inflammation-cognition axis.
Where Selank Fits in Research
| Research Focus | What’s Being Investigated |
|---|---|
| Anxiolytic Activity | GABAergic anxiety reduction without sedation |
| Cognitive Modulation | BDNF-linked memory formation and learning |
| Neuroprotective Signaling | Neuronal health and stress resilience |
| Immunomodulatory Effects | IL-6/cytokine regulation and CNS-immune interplay |
| Stress-Inflammation Axis | The link between cytokines, stress, and cognition |
| Enkephalin Metabolism | Enkephalinase inhibition and endogenous opioid tone |
What the Research Shows
| Finding | Result | Model / Context | Source |
|---|---|---|---|
| Anxiolytic potency | Comparable to diazepam/phenibut, no sedation | Elevated plus-maze (Seregin et al., PMID 19916388) | Spartan Peptides, 2026 |
| IL-6 reduction | Significantly lowered IL-6 | PHA-stimulated human PBMCs (Uchakina 2008, PMID 18683560) | Spartan Peptides, 2026 |
| Regulatory status | Approved in Russia (2009) as an anxiolytic | Not approved in the US/EU | Peptidepedia, 2026 |
| Dependence profile | No tolerance/dependence in preclinical models | Distinct from benzodiazepines | Regeneris, 2026 |
| Molecular weight | ~751.9 g/mol | Heptapeptide | Peptidepedia, 2026 |
The Honest Evidence Picture
I’d rather you hear this from me than a competitor’s comment section. Selank‘s clinical story is genuinely compelling — but it comes with real caveats. Most of the human trials were conducted in Russia with sample sizes that wouldn’t meet Western Phase 3 standards, the primary publications are largely in Russian-language journals, and independent replication in Western clinical settings hasn’t happened yet (Peptidepedia, 2026). The mechanistic data is solid and the safety signal is favorable, but “approved in Russia” isn’t the same as “validated worldwide.” That gap is exactly the kind of question active research exists to close.
Expanded Technical Specifications
| Property | Specification |
|---|---|
| Compound Name | Selank |
| CAS Number | 129954-34-3 |
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| Parent Peptide | Tuftsin (Thr-Lys-Pro-Arg) + Pro-Gly-Pro stabilizing extension |
| Molecular Formula | C₃₃H₅₇N₁₁O₉ |
| Molecular Weight | ~751.9 g/mol |
| Class | Synthetic heptapeptide (anxiolytic / immunomodulatory) |
| Purity Rating | >99% (HPLC & MS verified) |
| Format | White lyophilized powder |
| Solubility | Water-soluble |
| Storage | -20°C, protected from light and moisture |
The GLP1 Peptides Quality Standard
| Standard | What You Get |
|---|---|
| Verified 99%+ Purity | Every batch confirmed by HPLC and Mass Spectrometry |
| Advanced Lyophilization | Freeze-drying that protects the 7-residue sequence |
| Analytical Transparency | A batch-specific Certificate of Analysis (COA) with every order |
| Batch Consistency | Exact sequencing for a reliable research analog |
For a heptapeptide where each residue carries functional weight, that COA confirms you have genuine Selank — the correct tuftsin-derived sequence, not a truncated or mislabeled analog.
How to Reconstitute & Store Selank 10mg
You asked for the how-to, so here it is in full. Selank is water-soluble and reasonably robust, but standard peptide care protects your results.
- Reconstitute: let the sealed vial reach room temperature, then add bacteriostatic or sterile water gently down the inner glass wall (never onto the powder). Swirl until dissolved — don’t shake. Aliquot into single-use portions right away.
- Store powder: -20°C, sealed, away from light and moisture — stable long-term.
- Store reconstituted: 2–8°C, protected from light, with freeze-thaw cycles avoided.
- Inspect: discard any solution that turns cloudy or discolored.
Cold, dark, gentle, aliquoted — that discipline keeps a 10mg vial reliable across a full study.
Selank vs Semax vs Benzodiazepines
| Compound | Origin | Primary Action | Note |
|---|---|---|---|
| Selank (this product) | Tuftsin (IgG fragment) | Anxiolytic-first, with cognitive support | GABAergic + enkephalin + BDNF; no sedation/dependence |
| Semax | ACTH(4-7) | Nootropic-first, with mood support | Cognition-focused; dopaminergic/BDNF |
| Benzodiazepines | Synthetic drugs | Direct GABA-A agonism | Effective but sedating, tolerance- and dependence-forming |
The clean framing: Selank is the anxiety-first peptide, Semax the cognition-first one — the two are often studied side by side. And where benzodiazepines hit the GABA-A receptor directly (with all the baggage that brings), Selank works around it, which is the entire point of its design.
Selank 10mg for Sale — Shipping Worldwide
Our research-grade Selank 10mg ships as HPLC/MS-verified, COA-backed lyophilized vials, sealed and bench-ready. We fulfill orders for laboratories and independent researchers across the highest-demand markets:
- 🇺🇸 USA — fast domestic dispatch
- 🇨🇦 Canada — reliable cross-border delivery
- 🇩🇪 Germany (Deutschland) — trusted EU logistics
- 🇫🇷 France — secure European shipping
When you buy Selank 10mg from GLP1 Peptides, you get a verified tuftsin-derived heptapeptide with confirmed sequence and full documentation — the identity assurance that reliable neuropeptide research depends on.
FAQs about Selank 10mg
1. What is Selank 10mg? A 10mg vial of Selank, a synthetic heptapeptide analog of the immune peptide tuftsin (sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro), supplied as a lyophilized powder for anxiety, cognition, and immune research.
2. How does Selank reduce anxiety without sedation? It modulates GABAergic tone indirectly — increasing GABA-A receptor expression rather than binding the benzodiazepine site — so it calms anxiety without the sedation, tolerance, or dependence of benzodiazepines
3. What is Selank derived from? Tuftsin, a naturally occurring immunomodulatory fragment of immunoglobulin G, extended by three residues (Pro-Gly-Pro) to stabilize it and prolong its central activity.
4. Is Selank FDA approved? No. It was approved in Russia in 2009 as an anxiolytic, but it isn’t approved in the US or EU. This research-grade material is for laboratory use only.
5. What’s the difference between Selank and Semax? Selank is anxiety-first (derived from tuftsin); Semax is cognition-first (derived from ACTH 4-7). They’re often studied together as complementary neuropeptides
6. Does Selank affect the immune system? Yes — reflecting its tuftsin origin, it reduces pro-inflammatory cytokines like IL-6, TNF-α, and IL-1β under stress while preserving immune competence, which is central to stress-inflammation research.
7. How strong is the evidence for Selank? The mechanistic and preclinical data is solid, but most human trials are Russian, small by Western standards, and not independently replicated in the West — so weigh the findings with that context
8. What does BDNF have to do with Selank? Preclinical studies report Selank raises hippocampal BDNF, supporting neuroplasticity, the plausible basis for its studied effects on learning and memory.
9. How should Selank 10mg be stored? Lyophilized powder at -20°C, sealed and dark; reconstituted solution at 2–8°C, protected from light, with freeze-thaw avoided.
10. How do you reconstitute Selank? Room-temperature vial, bacteriostatic or sterile water added slowly down the glass wall, gentle swirl, then aliquot. The how-to section above covers it.
11. What purity should Selank be? Aim for 99%+ verified by HPLC and Mass Spectrometry, with a lot-specific COA confirming the sequence. Ours ships with that.
12. Where can I buy Selank 10mg internationally? GLP1 Peptides ships research-grade, COA-verified Selank 10mg to the USA, Canada, Germany, and France in sealed lyophilized vials.







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